Storz JF, Bridgham JT, Kelly SA, Garland T Jr. (2015) Genetic Approaches in Comparative and Evolutionary Physiology. Am J Physiol Regul Integr Comp Physiol, 309(3):R197-214
McKeown AN*, Bridgham JT*, Anderson DW, Murphy MN, Ortlund EA, Thornton JW. (2014) Evolution of novel DNA specificity in steroid receptors: mechanisms for the emergence of a new regulatory module. Cell,159(1):58-68
Bridgham JT, Keay J, Ortlund EA, Thornton JW. (2014) Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Receptor. PLoS Genetics, 10(1): e1004058
Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms, MJ, Gauthier MEA, Ortlund EA, Degnan BM, Thornton JW. (2010) Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. PLoS Biology, Oct 5;8(10). pii: e1000497
Bridgham JT, Ortlund EA, Thornton JW. (2009) An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature, 461(7263): 515-519
Carroll SM, Bridgham JT, Thornton JW. (2008) Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors. Mol. Biol. Evol. 25(12): 2642-2652
Bridgham JT, Brown JE, Rodriguez-Mari A, Catchen JM, Thornton JW. (2008) Evolution of a new function by degenerative mutation in cephalochordate steroid receptors. PloS Genet. 4(9): e1000191
Ortlund EA*, Brigham JT*, Redinbo MR, Thorton JW. (2007) Crystal structure of an ancient protein: evolution by conformational epistasis. Science. 317(5844): 1544-1548
Fox JE, Bridgham JT, Bovee TFH, Thornton JW. (2007) An evolvable oestrogen receptor activity sensor: development of a modular system for integrating multiple genes into the yeast genome. Yeast. 24(5): 379-390
Thornton JW, Bridgham JT. (2006) Using ancestral gene resurrection to understand the evolution of protein function. In: Liberles DA, ed. Ancestral Gene Reconstruction. Oxford University Press
Keay J, Bridgham JT, Thornton JW. (2006) The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications. Endocrinology. 147(8): 3861-3869
Bridgham JT, Carroll SM, Thornton JW. (2006) Evolution of hormone-receptor complexity by molecular exploitation. Science. 312(5770): 97-101
Johnson AL, Bridgham JT, Woods DC. (2004) Cellular mechanisms and modulation of activin A- and transforming growth factor beta-mediated differentiation in cultured hen granulosa cells. Biol. Reprod. 71(6): 1844-1851
Bridgham JT, Johnson AL. (2004) Alternatively spliced variants of Gallus gallus TNFRSF23 are expressed in the ovary and differentially regulated by cell signaling pathways. Biol. Reprod. 70(4): 972-979
Bridgham, JT and Johnson, AL. (2003) Characterization of chicken TNFR superfamily decoy receptors, DcR3 and osteoprotegerin. Biochem. Biophys. Res. Commun. 307(4): 956-961
Bridgham, JT, Wilder, JA, Hollocher, H and Johnson, AL. (2003) All in the family: evolutionary and functional relationships among death receptors. Cell Death and Differ. 10(1): 19-25
Johnson, AL, Solovieva, EV, and Bridgham, JT. (2002) Relationship between steroidogenic acute regulatory protein expression and progesterone production in hen granulosa cells during follicle development. Biol. Reprod. 67(4): 1313-1320
Johnson, AL, Langer, JS, and Bridgham, JT. (2002) Survivin as a cell cycle-related and antiapoptotic protein in granulosa cells. Endocrinology 143(9): 3405-3413
Bridgham, JT and Johnson, AL. (2002) Avian TVB (DR5-like) death receptor expression in hen ovarian follicles. Biochem. Biophys. Res. Commun. 291(2): 226-32
Johnson, AL and Bridgham, JT. (2002) Caspase-mediated apoptosis in the vertebrate ovary. Reproduction 124(1): 19-27
Bridgham, JT, Bobe, J. Goetz, FW, and Johnson, AL. (2001) Conservation of Death Receptor-6 (DR6) in avian and piscine vertebrates. Biochem. Biophys. Res Comm. 284:1109-1115
Bridgham, JT and Johnson, AL. (2001) Expression and Regulation of fas antigen and tumor necrosis factor type I in hen granulosa cells. Biol. Reprod. 65: 733-739
Johnson, AL and Bridgham, JT. (2001) Regulation of steroidogenic acute regulatory (StAR) protein messenger RNA in hen granulosa cells. Endocrinology 142 (7): 3116-3124
Johnson, AL, Bridgham, JT, and Swenson, JA. (2001) Activation of the AKT / Protein kinase B signaling pathway is associated with granulosa cell survival. Biol Reprod. 64:1566-1574
Bauer, MP, Bridgham, JT, Langenau, DM, Johnson, AL, and Goetz, FW. (2000) Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates. Mol. Cell. Endocrinol. 168:119-125
Johnson, AL and Bridgham, JT. (2000) Caspase-3 and -6 expression and enzyme activity in hen granulosa cells. Biol. Reprod. 62: 589-598
Johnson, AL, Bridgham, JT, and Jensen, T. (1999) Bcl-x Long protein expression and phosphorylation in granulosa cells. Endocrinology 140: 4521-4529
Johnson, AL, Bridgham, JT, Munks, MW, and Witty, JP. (1998) Characterization of the chicken interleukin-1 converting enzyme (caspase-1) cDNA and expression of caspase-1 mRNA in the hen. Gene 219 (1-2): 55-62
Johnson, AL, Bridgham, JT, Digby, MR, and Lowenthal JW. (1998) Expression of the inhibitor of T cell apoptosis (ita) gene in hen ovarian follicles during development. Biol. Reprod. 58: 414-420
Johnson, AL, Bridgham, JT, Witty, JP, and Tilly, JL. (1997) Expression of bcl-2 and nr-13 in hen ovarian follicles during development. Biol. Reprod. 57: 1096-1103
Johnson, AL, Bridgham, JT, Bergeron, L, and Yuan, J. (1997) Characterization of the avian ich-1 cDNA and expression of ich-1 long mRNA in the hen ovary. Gene 192 (2): 227-233
Johnson, AL, Bridgham, JT, and Anthony, RV. (1997) Expression of avian urokinase and tissue-type plasminogen activator mRNA during follicle development and atresia. Biol. Reprod. 56: 581-588
Dix, D, Bridgham, J, Broderius, M, and Eide, D. (1997) Characterization of the FET4 protein of yeast. Evidence for a direct role in the transport of iron. J. Biol. Chem. 272 (18): 11770-11777
Witty, JP, Bridgham, JT, and Johnson, AL. (1996) Induction of apoptotic cell death in hen granulosa cells by ceramide, in vitro. Endocrinology 137: 5269-5277
You, S, Bridgham, JT, Foster, DN, and Johnson, AL. (1996) Characterization of a chicken follicle-stimulating hormone receptor (cFSH-R) cDNA, and expression of cFSH-R mRNA in the ovary. Biol. Reprod. 55, 1055-1062
Johnson, AL, Bridgham, JT, and Wagner, B. (1996) Characterization of a chicken luteinizing hormone receptor (cLH-R) cDNA, and expression of cLH-R mRNA in the ovary. Biol. Reprod. 55: 304-309
Johnson, AL, Bridgham, JT, Witty, JP, and Tilly, JL. (1996) Susceptibility of avian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression. Endocrinology 137: 2059-2066
Dix, D, Bridgham, JT, Broderius, M, Byersdorfer, C, and Eide, D. (1994) The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae. J. Biol. Chem. 269: 26092-26099
Eide, DJ, Bridgham, JT, Zhao, Z, and Mattoon, R. (1993) The vacuolar H(+)-ATPase of Saccharomyces cerevisiae is required for efficient copper detoxification, mitochondrial function, and iron metabolism. Mol. Gen. Genetics. 241 (304): 447-456
Laurie, CC, Bridgham, JT, and Choudhary, M. (1991) Associations between DNA sequence variations and variation in expression of the Adh gene in natural populations of Drosophila melanogaster. Genetics 129 (2): 489-499
