Professor Lyle Isaacs
University of Maryland

Friday, April 11, 2014
2:30 pm, 331 Klamath Hall

Title: “Cucurbit[n]uril Molecular Containers: From Basic Science to Drug Delivery”

Abstract: 
In this talk I will discuss my groups work in the area of cucurbit[n]uril molecular containers with an emphasis on our recent work toward the use of CB[n]-type receptors in biomedical applications. Some topics to be discussed include: 1) the templated synthesis of methylene bridged glycoluril hexamer, its transformation into monofunctionalized CB[6] and CB[7] derivatives and CB[6] dimers, and studies of their self-assembly properties,1-4 2) the preparation of acyclic CB[n]-type receptors and their use as solubilizing agents for insoluble pharmaceuticals,5 3) the use of acyclic CB[n]-type receptors as in vitro and in vivo reversal agents for neuromuscular block,6 and drug delivery using targeted CB[7].7

Website: http://www.chem.umd.edu/lyle-isaacs/

Refreshments will be served at 2:00pm in 377 Klamath