In the U.S, human trafficking tends to occur around international travel-hubs, with a large Immigrant population, specifically California and Texas. The U.S. Justice Department estimates that 14,500–17,500 people are trafficked into the country every year.
North America detects that females are the main victims. About 60% of the approximate victims detected across the region whose age and sex profiles were reported were females.
In addition, adults are roughly 81% more victimised than children, where 60% are female victims and 21% are male.

Although there are multiple different forms of trafficking globally and nationally, specifically, this graph show that 55% of trafficking is for sexual exploitation, following 39% for forced labor and 6% for other unclassified reasons.

America and the Caribbean, who were neither trafficked domestically nor between neighboring countries, were mainly trafficked from origins less than a few hundreds miles from the border of the country where they were detected. Most of these victims were from South America.
The main destination for human trafficking is the United States in terms of South and Central America.
https://www.unodc.org/documents/data-and-analysis/glotip/2016_Global_Report_on_Trafficking_in_Persons.pdf
What is being done
The Trafficking Victims Protection Act (TVPA) was authorized in 2000 and was the first federal law to address sex trafficking and labor trafficking in the United States. The TVPA focused on the prevention and protection for trafficking survivors, as well as prosecution for traffickers, taking its ideals from the foundations of NGO’s anti-slavery international.
The TVPA was reauthorized multiple time, each reauthorization offered positive changes. For example, the TVPRA of 2008 required the Department of Labor to publish a list of products produced by child labor or forced labor. But the TVPRA expired in 2011, and is in need of an update to keep up with the rapidly evolving landscape of human trafficking.
This past year, a bill to reauthorize the TVPRA has been reintroduced to Congress. It holds government contractors accountable for using foreign labor recruiters that use exploited labor, helps law enforcement prevent and prosecute sex tourism, and creates a grant-making program to prevent trafficking in humanitarian crises (such as in the case of Haiti or Syria).
On the state level, while there has been vast improvement in some legislation, a few states have a long way to go. Massachusetts, rated one of the most improved states by the Polaris Project , created a Human Trafficking Task Force, which strengthens protections for victims of trafficking and makes using the internet as a trafficking tool a punishable offense.
On the other hand, there are states like Wyoming, where until 2013, no state law existed to punish traffickers. Wyoming joins the ranks as the last state to ban human trafficking with Governor Matt Mead signing the first anti-trafficking law in Wyoming, making it illegal to traffic individuals for commercial sex or forced labor.
https://www.themuse.com/advice/whats-being-done-to-stop-human-trafficking