Publications
(# = corresponding author; * = equal contributions; †= UO graduate student; ‡ = UO undergraduate)
Molecular basis of product recognition during PIP5K-mediated production of PI(4,5)P2 with positive feedback
Duewell BR†, Faris KA‡, Hansen SD#. (2024). Journal of Biological Chemistry. link to article
A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane
Wills RC, Doyle CP, Zewe JP, Pacheco J, Hansen SD, Hammond GR#. (2023). Journal of Cell Science. link to article
Mechanisms controlling membrane recruitment and activation of the autoinhibited SHIP1 inositol 5-phosphatase
Waddell GL†, Drew EE†, Rupp HP‡, Hansen SD#. (2023). Journal of Biological Chemistry. link to article
Molecular dissection of PI3Kβ activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
Duewell BR*†, Wilson NE*†, Bailey GM‡, Peabody SE‡, Hansen SD#. (2023). eLife. link to article
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Harris NJ, Jenkins ML, Rathinaswamy MK, Parson M, Ranga-Prasad H, Dalwadi U, Moeller BE, Skeekey E, Hansen SD, Yip CK, Burke JE#. (2023). eLife. link to article
Molecular basis for differential activation of p101 and p84 complexes of PI3K𝛾 by Ras and GPCRs
Rathinaswamy MK, Jenkins ML, Duewell BR†, Zhang X, Harris NJ, Evans JT, Stariha JT, Dalwadi U, Fleming KD,Ranga-Prasad H, Yip CK, Williams RL, Hansen SD#, Burke JE#. (2022). Cell Reports. link to article
Membrane-mediated dimerization potentiates PIP5K lipid kinase activity
Hansen SD#, Lee AA, Duewell BR†, and Groves JT. (2022). eLife. link to article
Stochasticity and positive feedback enable enzyme kinetics at the membrane to sense reaction size
Lee AA, Huang WYC, Hansen SD, Kim NH, Alvarez S, and Groves JT#. (2021). Proc Natl Acad Sci USA. Jul 5. pii: 201901744. link to article
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation
Rathinaswamy MK, Dalwadi U, Fleming KD, Adams C, Stariha J, Pardon E, Baek M, Vadas O, DiMaio F, Steyaert J, Hansen SD, Yip CK#, & Burke JE#. (2021). Science Advances. 7(35), eabj4282. link to article
Rapid and Inexpensive Preparation of Genome-Wide Nucleosome Footprints from Model and Non-Model Organisms
McKnight LE, Crandall JG, Bailey TB, Banks OGB, Orlandi K, Truong VN, Donovan DA, Waddell GL, Wiles ET, Hansen SD, Selker EU, and McKnight JN#. (2021). Star Protocols. vol 2, Issue 2, 100486, ISSN 2666-1667. link to article
Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction
Hansen SD#, Huang WYC, Lee YK, Bieling P, Christensen SM, Groves JT#. (2019). Proc Natl Acad Sci USA. Jul 5. pii: 201901744. link to article
WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation
Bieling P*, Hansen SD*, Akin O, Li TD, Hayden CC, Mullins RD#, Fletcher DA#. (2018). EMBO Journal. Jan 4;37(1):102-121. link to article
Controlling styrene maleic acid lipid particles through RAFT
Smith AA, Autzen HE, Laursen T, Wu V, Yen M, Hall A, Hansen SD, Cheng Y, Xu T#. (2017). Biomacromolecules. Nov 13;18(11):3706-3713. [pubmed]
Bacterial Microtubules Exhibit Polarized Growth, Mixed-Polarity Bundling, and Destabilization by GTP Hydrolysis
Celis CD, Risca V, Hurtado F, Polka J, Hansen SD, Maturana D, Lagos R, Mullins RD, Monasterio O#. (2017). Journal of Bacteriology. [pubmed]
Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate
Lee YK, Low-Nam ST, Chung JK, Hansen SD, Lam HYM, Alvarez S, Groves JT#. (2017). Nature Communications. Apr 28;8:15061. doi: 10.1038/ncomms15061. [pubmed]
Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
Huang WY, Yan Q, Lin WC, Chung JK, Hansen SD, Christensen SM, Tu HL, Kuriyan J, Groves JT#. (2016). Proc Natl Acad Sci USA. Jul 19;113(29):8218-23. doi:10.1073/pnas. 1602602113. [pubmed]
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.
Hansen SD# and Mullins RD#. (2015). eLife. Aug 21;4. doi: 10.7554/eLife.06585. [pubmed]
Ras activation by SOS: allosteric regulation by altered fluctuation dynamics
Iversen L, Tu HL, Lin WC, Christensen SM, Abel SM, Iwig J, Wu HJ, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu CH, Stamou D, Chakraborty AK, Kuriyan J, Groves JT#. (2014). Science. Jul 4;345(6192):50-4. [pubmed]
Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation
Pokutta S, Choi HJ, Ahlsen G, Hansen SD, Weis WI#. (2014). Journal Biological Chemistry. May 9;289(19):13589-601. [pubmed]
H-Ras forms dimers on membrane surfaces via a protein-protein interface
Lin W, Iversen L, Tu H, Rhodes C, Christensen SM, Iwig JS, Hansen SD, Huang WY, and Groves JT#. (2014). Proc Natl Acad Sci USA. Feb 25;111(8):2996-3001. [pubmed]
αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors
Hansen SD*, Kwiatkowshi AV*, Ouyang CY, Liu H, Pokutta S, Watkins SC, Volkmann N, Hanein D, Weis WI, Mullins RD, and Nelson WJ#. (2013). Molecular Biology of the Cell. Dec;24(23):3710-20. [pubmed]
Cytoplasmic Actin: Purification and Single Molecule Assembly Assays
Hansen SD, Zuchero BJ, and Mullins RD. (2013). A. S. Coutts, ed. Methods in Molecular Biology (Clifton, N.J.). 1046:145-70. [pubmed]
In vitro studies of actin filament and network dynamics
Mullins RD and Hansen SD. (2013). Current Opinion in Cell Biology. Dec 22; pii: S0955-0674 (12)00190-1. [pubmed]
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion
Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, and Brugge JS. (2012). Cancer Cell. Nov 13;22(5):615-30. [pubmed]
Chromosome passenger complexes control anaphase duration and spindle elongation via a kinesin-5 brake
Rozelle DK, Hansen SD, and Kaplan KB#. (2011). Journal of Cell Biology. 193(2). [pubmed]
VASP is a processive actin polymerase that requires monomeric actin for barbed end association
Hansen SD and Mullins RD#. (2010). Journal of Cell Biology. 191(3):571-84. [pubmed]
A novel role for the CBF3 kinetochore-scaffold complex in regulating septin dynamics and cytokinesis
Gillis AN, Thomas S, Hansen SD, and Kaplan KB#. (2005). Journal of Cell Biology. 171(5):773-84. [pubmed]
