Aging

Instructor: George Sprague
gsprague@molbio.uoregon.edu

Review

Replicative Aging in Yeast: The Means to the End

Sir2 and calorie restriction in yeast: A skeptical perspective

The Plasticity of Aging: Insights from Long-Lived Mutants

The genetics of ageing

Research

Calorie restriction extends yeast life span by lowering the level of NADH

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction

Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

Genes that Regulate Both Development and Longevity in Caenorhabditis elegans

daf-2, an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

A C. elegans mutant that lives twice as long as wild type

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

A systematic RNAi screen for longevity genes in C. elegans

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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