Moss to Prevent Loss?: Exploring Methods for Halting Permafrost Deterioration in Siberia

Presenter(s): Maya O’boyle − Russian, East European And Eurasian Studies (Reees), International Studies

Faculty Mentor(s): Dave Sutherland

Poster 175

Research Area: Natural/Physical Science (Cryosphere)

Permafrost, a layer of subsurface that remains frozen for two or more uninterrupted years, plays a significant role in the global cryospheric system. Permafrost lends stability to some of the world’s most barren environments, perhaps most important to no other place than Russia, of which it covers “more than 60%” (Anisimov and Reneva 169). This particularly applies
to the Siberian region, whose factories, nuclear plants, large cities, and abundant natural resources remain under threat, vulnerable to permafrost thawing that often leaves the ground unstable, contaminated by leached mercury, and disrupted of vegetation. This permafrost deterioration also impacts the global climate, “acting through release of greenhouse gases to the atmosphere” and accelerating climate change (Anisimov and Reneva 174). However, while many studies have been conducted on thawing impacts, few have explored the roll vegetation can have in preventing permafrost shrinkage, particularly native mosses, which serve as an effective natural insulator. This study will explore the impacts of permafrost thawing on these native mosses, paying particular attention to how thawing affects moss thickness, in order to better understand and predict Siberian climate change. What can studying this moss cover reveal about methods to halting permafrost deterioration and global warming?

How Melting Rates of East and West Antarctic Ice Sheets Differ and What This Means for Global Mean Sea-Level Rise

Presenter(s): Kenzie Hudler − Public Relations

Faculty Mentor(s): Dave Sutherland

Poster 159

Research Area: Natural/Physical Science

Glaciers are formed from heavy snow accumulation and compaction. Glaciers also experience ablation or surface melting, which involves a loss of glacier mass, as glaciers are viscous fluids. There are numerous factors that control the ice flow speed of glaciers, including temperature of the ice, slope of the glacier, thickness of the ice, and the subglacial environment. Greenhouse gas emissions released into our atmosphere cause a warming that even the continental glaciers of East and West Antarctica cannot withstand, resulting in a rise in global sea-level. Here we show that the West Antarctic ice sheet is melting at a faster rate than the East Antarctic ice sheet, which seems relatively stable at the moment. However, recent data has revealed that the East Antarctic ice sheet could be more vulnerable to climate change than originally thought, after analyzing its past behavior in previously similar climate conditions. Consequently, global mean sea-level is rising at an accelerating rate. The results demonstrate how differently the East and West Antarctic ice sheets are melting, and how these increasing melting rates are impacting global sea-levels. My essay will serve as a comparison of the evolution/recent patterns of retreat and melting in the East and West Antarctic ice sheets and a starting point for how these patterns are impacting global sea-levels. Furthermore, the Antarctic glaciers are melting at accelerating rates, and even cutting back on greenhouse gas emissions may not be able to reverse this process.

Heavier Snowfall and Snow Distribution Patterns as a Result of Global Warming

Presenter(s): Isabella Cao − Journalism

Faculty Mentor(s): Dave Sutherland

Poster 144

Research Area: Natural/Physical Science

Low temperatures and the presence of moisture are conditions that allow for snowfall. When parcels of warm air containing moisture rise and cool, the water vapor condenses to form clouds. These clouds form precipitation, in the form of either water droplets or tiny ice crystals depending on surrounding air temperature. Precipitation and snowfall are a normal part of the hydrological cycle; however, global warming has changed the hydrological cycle and thus affects patterns of snowfall. A 4% increase in atmospheric moisture has been observed (warmer atmospheres holding 7% more moisture per 1°C). Many studies have been done on global warming’s contribution to dwindling snowpacks and high rates of snowmelt, however, few have studied heavy snowfall as an effect of climate change. Here I show patterns of decreased and increased snowfall in various regions. I found that warming of ocean surfaces and other water supplies can result in patterns of heavier snowfall. Japan predicts decreases in total winter snowfall, as well as an unusual heavy snowfall occurrence every 10 years. Further, I found that while most regions experience an overall decrease in snow, the distribution pattern changes significantly, with some places having much less or more more than usual. Climate change does not always result in immediate depletion of snow, but rather a continuous changing pattern that shows decreasing over time. This report could instigate more accurate portrayals of snowfall patterns, leading to more accurate studies. These findings will be useful in better utilizing water resources that rely on snowfall.

Industrialization vs. Environmental Protection: The Intersection of a Growing Asian Economy and a Melting Himalayan Cryosphere

Presenter(s): Payton Becker − Economics, Political Science

Faculty Mentor(s): Dave Sutherland

Poster 141

Research Area: Natural/Physical Science

As a region of the world with great potential for economic growth, Southern Asia faces unprecedented levels of air pollution and snow melt. Darkening the Himalayan snow’s surface and increasing its ability to absorb sunlight, the presence of natural and man-made air particulates on ice trigger glacial melting that requires human response. Emission-creating practices in the industrial and agricultural sectors – such as those that originate from factories, long-distance transportation, and biomass burning (“slash and burn” farming) – combine with natural phenomena such as wind storms to spread Black Carbon and other aerosols. These contributors to air pollution lower the single-scattering albedo of snow after landing on it, leading to potential catastrophes and the need for human-initiated mitigation. As this region of the cryosphere continues to warm, countries such as Nepal and India must face the question of whether to formulate policies that pursue economic development or responsible climate practices. Here we show the effects of air particulates on glacial albedo using data collected over multiple years as well as society’s response to the symptoms of Himalayan melting. Actors working to prevent and reduce the severity of the problem take the form of governmental institutions implement policies, spanning from within Himalayan countries to the international community. At risk of facing destruction from a melting cryosphere, human lives and sacred places within the Asian continent rest in the hands of those with the power to regulate industrialization and raise albedo to levels that better reflect the sun’s rays.

Use of Dichloro-diphenyl-trichloro-ethane and Alternative Methods to Fight Malaria in Sub- Saharan Africa

Presenter(s): Sarah Wheeler − Biology

Faculty Mentor(s): William Bradshaw, Melissa Graboyes

Poster 17

Research Area: Natural/Physical Science

Malaria is a disease that seems foreign to many; a distant memory. Despite the lack of awareness of the breadth of this disease, the World Health Organization reported 216 million cases of malaria across the world in 2016, 445,000 of which resulted in fatalities. While malaria was eradicated in the US in 1951, it’s present across the globe, with the epicenter of the endemic in Sub-Saharan Africa. Malaria is a vector-borne disease, meaning an organism transfers the disease to a host.
The vector for malaria is Anopheles gambiae, which infects the host with the parasite Plasmodium. Eradication has been successful through the use of dichloro-diphenyl-trichloro-ethane (DDT) by spraying the interior of homes in the past, but the organic pesticide has been banned in many countries. This research focuses on how eradication occurred in the past, what is used today to fight malaria in Sub-Saharan Africa and methods currently being developed in laboratories. Specifically, a meta-analysis was conducted of studies concerning the effects of DDT on the environment and human health, mechanisms of A. gambiae mutations that lead to DDT resistance, alternative methods of fighting malaria and their success rate, as well as cultural and financial barriers that prevent eradication. Comparison of these studies suggests that a rotation of pesticides, including DDT in IRS is effective when paired with pesticide-treated nets.

Characterization of GaSbP as a photocathode For Water-Splitting

Presenter(s): Ashlee Vise − Chemistry

Faculty Mentor(s): James Young

Poster 49

Research Area: Natural/Physical Science

Funding: Department of Energy SULI Program

A photoelectrochemical cell (PEC) functions as an integrated water-splitting device using the sun’s energy to produce clean hydrogen gas. Barriers in the PEC field includes finding a cathode that has a (1) valence and conduction band that straddles the redox potentials of H2 and O2 , (2) photocurrent density greater than 1 mA/cm2, and (3) high photocurrent onset potential. Theoretical calculations have shown that different compositions of GaSbxP1-x alloys may meet these criteria. For this reason, we grew samples and performed a variety of characterization techniques to analyze the films. The present work shows that films with less than 13% antimony have IPCE (incident photon-to-current efficiency) of up to 60%, direct and indirect p-type band gaps that lie between ~2.0 and 2.2 eV, and photocurrent densities that reach 2 mA/cm2. These films show promising characteristics although they do not meet all of the requirements to perform unassisted water-splitting. Future work for this study includes growing more films that span a wider composition range in order to fully characterize the GaSbxP1-x material system.

PTPN11 S502P and Tyrosine Kinase Non-Receptor-2 increase RAS/MAPK signaling in Acute Myeloid Leukemia

Presenter(s): Corinne Togiai − Biology

Faculty Mentor(s): Chelsea Jenkins, Dr. Bill Chang

Oral Session 3M

Research Area: Natural/Physical Science (Cancer Biology)

Funding: OHSU Knight Cancer Institute, Oregon Health and Science University, Howard Hughes Medical Institute, Druker Laboratory, Dr. Brian Druker, Dr. Bill Chang, Dr. Jeff Tyner and Dr. Chelsea Jenkins

PTPN11 is a gene which encodes the protein tyrosine phosphatase SHP2, an auto-inhibited protein that dephosphorylates targets in many of the proliferative pathways such as Ras/MAPK. This gene, PTPN11, is the driving force in 35% of Juvenile Myelomoncytic Leukemia (JMML) patients and 10% of Acute Myeloid Leukemia (AML) patients. Moreover, cells from a JMML patient were found to be sensitive to tyrosine kinase inhibitor dasatanib. This is thought due to interactions between PTPN11 and tyrosine non-kinase 2 (TNK2), which is a dasatanib target. Therefore, we hypothesized that HEK 293 T17 cells co-transfected with mutant PTPN11 S502P and TNK2 will display decreased phospho-TNK2 and increased phospho-ERK, as seen in the JMML mutant PTPN11 E76K. In my project, I worked with PTPN11 mutation identified in an AML patient sample (S502P) that has shown sensitivity to the drug Dasatanib, a kinase inhibitor that blocks the action of abnormal proteins that signal cells to proliferate, ultimately helping stop the spread of cancer cells. I performed multiple western blots consisting of: transfections, gel electrophoresis, and protein detection. Results show S502P mutant PTPN11 acts like E76K mutant in that it activates the RAS/MAPK pathway, and S502P mutant PTPN11 dephosphorylates TNK2. In conclusion, the patient sample S502P mutant has shown a dephosphorylating effect on TNK2 that has not been seen in any previous studies. Data suggests that this mutant also works with TNK2 to increase RAS/MAPK signaling. Through this interaction this mutation can be tested and targeted by Dasatinib to stop the proliferation of leukemic cells.

A Decision Tree Model to Predict Cervical Cancer Screening

Presenter(s): Seth Temple − Mathematics

Faculty Mentor(s): Stephen Fickas

Data Story

Research Area: Natural/Physical Science

I develop a decision tree model to predict if a female patient will be screened for cervical cancer. This project interests me because I want to apply machine learning to improve the health care system. I access the data from the website Kaggle. I use the pandas package to clean the data, and I wrangle some numerical columns with k-means clustering. Graphs will be produced by matplotlib. This project gives me practice in modeling with binary variables. As I plan to enter the actuarial field, this skill set is needed in building fraud and inspection models.

The Sum of My Parts: A Genetic Inquiry with 23andMe

Presenter(s): Seth Temple − Mathematics

Faculty Mentor(s): Amy Connolly

Oral Session 2CS

Research Area: Natural/Physical Science

Direct-to-consumer genetic tests provide an accessible way for individuals to learn about their genome. This creative project is an outlet for me to talk about personal genomics and what I learned from taking 23andMe’s genetic test. I write to a hypothetical child, explaining how genes affect biological processes and analyzing the results of my genetic tests. Specifically, I investigate male-pattern baldness, a gene encoding for fast-twitch muscle fibers, hereditary fructose intolerance, a genetic risk factor for late-onset Alzheimer’s disease, and ancestry reports. I reflect on how I respond emotionally to these results and on how these genes impact my life. This analysis draws on 23andMe’s reports and the current scientific literature. Controversial topics such as the epigenetics of homosexuality and genetic discrimination in insurance are discussed as well.

The Effects of a Fatiguing Run on Hip Abductor Muscle Strength and Pelvic Kinematics

Presenter(s): Hao Tan − Human Physiology

Co Presenter(s): Colin Lipps

Faculty Mentor(s): Li-Shan Chou, JJ Hannigan

Poster 24

Research Area: Natural/Physical Science

Funding: UROP Mini-Grant, Sue Grigsby Scholarship, William and Marjorie Shearon Memorial Scholarship

Existing literature has identified several risk factors for the development of lower limb pathologies in recreational runners, including hip abductor muscle strength deficits as well as abnormal patterns in pelvic running kinematics. Studies have indicated that hip abductor muscles play a role in stabilizing the hip during running and that hip abductor strength deficits are associated with the development of overuse injuries as well as abnormal pelvic kinematics while performing tasks upright. However, the relationship between hip abductor strength deficits and abnormal pelvic kinematics while running remains unclear. This study intends to clarify the relationship between hip abductor muscle fatigue and associated pelvic kinematic changes in healthy runners by implementing a novel 30-minute lactate threshold treadmill run as a fatigue protocol while investigating pelvic kinematic changes at 7 equidistant time points over the course of the protocol. In terms of analyzing pelvic kinematics, this study implemented a dynamical systems approach, analyzing the variability of Trunk-Pelvis and Pelvis- Thigh segment couplings in the 3 anatomical planes, as well as an analysis of individual pelvic kinematic variables, specifically pelvic drop, hip adduction, trunk lean, and hip internal rotation. 23 subjects, between the ages of 18 – 40 who have not sustained major running related injuries and regularly run at least 20 miles a week, participated in this study. Participants performed a triplet of hip abductor muscle maximal voluntary contractions (MVCs) to establish a baseline and a post-fatigue strength assessment before and after a 30-minute fatiguing run, during which kinematic changes were assessed. Using a significance threshold of 0.05, it was found that hip abductor strength decreased significantly following the fatigue protocol (p < 0.0001) while pelvic drop significantly increased following the fatigue protocol (p < 0.001). No significant changes were observed in trunk lean, hip adduction, or hip internal rotation. The results of a repeated measures one-way ANOVA used on the entire participant pool indicated that there were no significant changes in variability between the 7-time points for both Trunk-Pelvis and Pelvis-Thigh coupled segments in the three anatomical planes. However, paired t-tests indicated that female participants experienced a significant decrease in variability within the sagittal plane of Pelvis-Thigh (p < 0.001) coupled segments and the frontal plane of Trunk-Pelvis (p < 0.01) coupled segments following the fatigue protocol. The experimental results indicate that a 30-minute lactate threshold treadmill run is an effective method of inducing hip abductor fatigue and potential increases in pelvic drop. Additionally, the findings of the dynamical systems approach used implicates that females may be more prone to lower limb overuse pathologies, which is consistent with the experimental findings of past studies.