Presenter(s): Sydney Kobak—Human Physiology
Faculty Mentor(s): Dylan Sieck
Session: Prerecorded Poster Presentation
This study aims to gain a deeper mechanistic understanding of how the body adapts to chronic endurance exercise stress . It is known that repeated exercise stress leads to multiple adaptations that decrease all cause mortality and development of cardiovascular disease, while increasing
the ability to preform further work . This experiment examined how these variables changed during 6-week exercise training regimen with and without antihistamines, which caused the sustained post-exercise vasodilated state to be inhibited . There were two groups that went through the training regimen: the control group (placebo) and the histamine receptor blockade group (antihistamine) . Vascular measurements were taken using applanation tonometry with pencil like pressure transducers placed over the artery of interest . Results showed that VO2peak increased by ~11% for both groups . Arterial stiffness, measured as pulse wave velocity (PWV), of the conduit arteries did not significantly change, however, there was a significant increase in PWV in the blockade group, while the control group decreased . This finding could indicate that the sustained post-exercise vasodilated state is contributing to vascular adaptation on peripheral arteries .