Determining Scrib binding partners relevant to its spindle orienting function

Presenter(s): Hussein Al-Zubieri – Biochemistry

Faculty Mentor(s): Ken Prehoda, Nicole Paterson

Poster 82

Research Area: Molecular Biology

Asymmetric stem cell division requires a mitotic spindle oriented relative to its axis of polarity. Spindle orientation determines where the cleavage furrow is positioned, thereby determining the location of cell division. Without a correctly oriented spindle, tumorigenesis can occur. Indeed, many of the proteins in the pathway are tumor suppressors. Two pathways have been found to position the spindle, Mud pathway and Dlg pathway. Both are required for spindle orientation. Our research focuses on a Dlg pathway protein member called Scrib which is a tumor suppressor protein that has been shown to be required for spindle orientation. The function of Scrib is not yet fully understood, and our research is focused on discovering the mechanism of its function in this process. A starting point for identifying function is to test the requirement of the functional domains of Scrib in vivo, and determine the specific function of these domains in vitro. My project is to determine the Scrib binding partners relevant to its spindle orienting function.

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