The “Stress-Chip” is a microfluidic chip that allows low population density (~1 animal per arena) animal culturing to facilitate high-throughput longitudinal studies. The single arenas use a structured artificial dirt pillar arrangement to promote plate-like behaviors while maintaining the benefits of a flow-through aqueous environment. While developed for stress analysis, this research platform should be applicable to a variety of research questions, as survivorship is a fundamental measurement used in C. elegans research as diverse as anthelmintic-drug screening, aging studies, Alzheimer’s modeling, and toxicology studies.
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Preprint:
The Stress-Chip A microfluidic platform for stress analysis in Caenorhabditis elegans