Publications

2026

  • Dantas WS, Zunica ERM, Heintz EC, Hoppel CL, Hill CM, Morrison CD, Axelrod CL, Davuluri G, Kirwan JP. Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK-ULK1-Mediated Mitochondrial Quality Control. Aging Cell. 2026 Feb;25(2):e70386. doi: 10.1111/acel.70386. https://pubmed.ncbi.nlm.nih.gov/41549510/

2025

  • Mancini MC, McCall CP, Noland RC, Dantas WS, Heden TD. Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma. Oncogenesis. 2025 Dec 8;15(1):3. doi: 10.1038/s41389-025-00593-y. https://pubmed.ncbi.nlm.nih.gov/41360863/
  • Gil S, Murai IH, Dantas WS, Merege-Filho CAA, Leitão AE, Nicoletti CF, Lima AP, Benatti F, Cleva R, Santo MA, Kirwan JP, Gualano B, Roschel H. Roux-en-Y Gastric Bypass Improves Insulin Response and Secretion of GLP-1 and PYY in Response to Postprandial Acute Exercise. Obes Surg. 2025 Nov 14. doi: 10.1007/s11695-025-08327-0. https://pubmed.ncbi.nlm.nih.gov/41238973/
  • Casale AR, Lemes IR, Smaira FI, Astley C, de Oliveira Júnior GN, Sá-Pinto AL, Ribeiro ACM, Godoy-Santos AL, Lima M, Carneiro CG, Buchpiguel CA, Dantas WS, Axelrod CL, Javvadi P, Ghosh S, Kirwan JP, Roschel H, Gualano B. Interleukin-6 Blockade Does Not Impair Exercise-Induced Glucose Uptake and Insulin Sensitivity in Rheumatoid Arthritis. Am J Physiol Endocrinol Metab. 2025 Oct 17. doi: 10.1152/ajpendo.00348.2025. https://pubmed.ncbi.nlm.nih.gov/41106846/
  • Heintz EC, Dantas WS, Taylor AL, Zunica ERM, Belmont KP, Mey JT, Beyl R, Vandanmagsar B, Parry HA, Ajayi P, Glancy B, Axelrod CL, Kirwan JP. Miro1 Mediates Skeletal Muscle Insulin Resistance in Type 2 Diabetes. medRxiv [Preprint]. 2025 Aug 10:2025.08.06.25333143. https://pubmed.ncbi.nlm.nih.gov/41030931/
  • Pandey P, Wall PK, Lopez SR, Zunica ERM, Dubuisson OS, Dantas WS, Davuluri G, Taylor AL, Wall TK, Juge HJ, Kirwan JP, Axelrod CL, Johnson AE. A familial natural short sleep mutation in dec2 extends healthspan and lifespan in Drosophila. iScience. 2025 Aug 21;28(9):113388. https://pubmed.ncbi.nlm.nih.gov/40989023/
  • Dantas WS, Heintz EC, Zunica ERM, Mey JT, Erickson ML, Belmont KP, Taylor AL, Davuluri G, Fujioka H, Fealy CE, Hoppel CL, Axelrod CL, Kirwan JP. Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes. J Cachexia Sarcopenia Muscle. 2025 Apr;16(2):e13763. https://pubmed.ncbi.nlm.nih.gov/40035128/

2024

  • Axelrod CL, Hari A, Dantas WS, Kashyap SR, Schauer PR, Kirwan JP. Metabolomic Fingerprints of Medical Therapy Versus Bariatric Surgery in Patients With Obesity and Type 2 Diabetes: The STAMPEDE Trial. Diabetes Care. 2024 Nov 1;47(11):2024-2032. https://pubmed.ncbi.nlm.nih.gov/39311919/
  • Zunica ERM, Heintz EC, Dantas WS, Hebert RC, Tanksley M, Beyl RA, Mader EC Jr, Kirwan JP, Axelrod CL, Singh P. Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial. Physiol Rep. 2024 Feb;12(3):e15948. doi: 10.14814/phy2.15948. https://pubmed.ncbi.nlm.nih.gov/38346816/
  • Taylor AL, Dubuisson O, Pandey P, Zunica ERM, Vandanmagsar B, Dantas WS, Johnson A, Axelrod CL, Kirwan JP. Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster. Aging Cell. 2024 May;23(5):e14107. doi: 10.1111/acel.14107. Epub 2024 Feb 11. https://pubmed.ncbi.nlm.nih.gov/38343281/

2023

  • Mey JT, Vandagmansar B, Dantas WS, Belmont KP, Axelrod CL, Kirwan JP. Ketogenic propensity is differentially related to lipid-induced hepatic and peripheral insulin resistance. Acta Physiol (Oxf). 2023 Dec;239(4):e14054. doi: 10.1111/apha.14054. Epub 2023 Oct 16. https://pubmed.ncbi.nlm.nih.gov/37840478/
  • Axelrod CL, Langohr I, Dantas WS, Heintz EC, Vandanmagsar B, Yang S, Zunica ERM, Townsend RL, Albaugh VL, Berthoud HR, Kirwan JP. Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice. Obesity (Silver Spring). 2023 Dec;31(12):2960-2971. doi: 10.1002/oby.23876. Epub 2023 Sep 20. https://pubmed.ncbi.nlm.nih.gov/37731222/
  • Oliveira AB, Katzmarzyk PT, Dantas WS, Benseñor IJM, Goulart AC, Ekelund U. Profile of leisure-time physical activity and sedentary behavior in adults in Brazil: a nationwide survey, 2019. Epidemiol Serv Saude. 2023 Aug 11;32(2):e2023168. doi: 10.1590/S2237-96222023000200016. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37585879/
  • Pandey P, Wall PK, Lopez SR, Dubuisson OS, Zunica ERM, Dantas WS, Kirwan JP, Axelrod CL, Johnson AE. A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila. Res Sq [Preprint]. 2023 Jun 2:rs.3.rs-2882949. doi: 10.21203/rs.3.rs-2882949/v1. https://pubmed.ncbi.nlm.nih.gov/37398097/
  • Axelrod CL, Dantas WS, Kirwan JP. Sarcopenic obesity: emerging mechanisms and therapeutic potential. Metabolism. 2023 Sep;146:155639. doi: 10.1016/j.metabol.2023.155639. Epub 2023 Jun 26. https://pubmed.ncbi.nlm.nih.gov/37380015/
  • Pandey P, Wall PK, Lopez SR, Dubuisson OS, Zunica ERM, Dantas WS, Kirwan JP, Axelrod CL, Johnson AE. A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila. bioRxiv [Preprint]. 2023 Apr 26:2023.04.25.538137. doi: 10.1101/2023.04.25.538137. https://pubmed.ncbi.nlm.nih.gov/37163058/
  • Merege-Filho CAA, Gil SS, Kirwan JP, Murai IH, Dantas WS, Nucci MP, Pastorello B, de Lima AP, Bazán PR, Pereira RMR, de Sá-Pinto AL, Lima FR, Brucki SMD, de Cleva R, Santo MA, Leite CDC, Otaduy MCG, Roschel H, Gualano B. Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial. Int J Obes (Lond). 2023 Mar;47(3):165-174. doi: 10.1038/s41366-022-01251-8. Epub 2022 Dec 30. https://pubmed.ncbi.nlm.nih.gov/36585494/

2022

  • Dantas WS, Zunica ERM, Heintz EC, Vandanmagsar B, Floyd ZE, Yu Y, Fujioka H, Hoppel CL, Belmont KP, Axelrod CL, Kirwan JP. Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1821-1836. doi: 10.1002/jcsm.12982. Epub 2022 Mar 19. https://pubmed.ncbi.nlm.nih.gov/35304976/
  • Hoddy KK, Axelrod CL, Mey JT, Hari A, Beyl RA, Blair JB, Dantas WS, Kirwan JP. Insulin resistance persists despite a metabolically healthy obesity phenotype. Obesity (Silver Spring). 2022 Jan;30(1):39-44. doi: 10.1002/oby.23312. Epub 2021 Nov 24. https://pubmed.ncbi.nlm.nih.gov/34816598/

2021

  • Pinto AJ, Meireles K, Peçanha T, Mazzolani BC, Smaira FI, Rezende D, Benatti FB, Ribeiro ACM, Pinto ALS, Lima FR, Shinjo SK, Dantas WS, Mellett NA, Meikle PJ, Owen N, Dunstan DW, Roschel H, Gualano B. Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis. Am J Physiol Endocrinol Metab. 2021 Dec 1;321(6):E782-E794. doi: 10.1152/ajpendo.00259.2021. Epub 2021 Oct 25. https://pubmed.ncbi.nlm.nih.gov/34693756/
  • Gil S, Kirwan JP, Murai IH, Dantas WS, Merege-Filho CAA, Ghosh S, Shinjo SK, Pereira RMR, Teodoro WR, Felau SM, Benatti FB, de Sá-Pinto AL, Lima F, de Cleva R, Santo MA, Gualano B, Roschel H. A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1440-1455. doi: 10.1002/jcsm.12815. Epub 2021 Oct 19. https://pubmed.ncbi.nlm.nih.gov/34666419/
  • Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP. Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab. 2021 Oct 9;9(1):36. doi: 10.1186/s40170-021-00274-5. https://pubmed.ncbi.nlm.nih.gov/34627389/
  • King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP. Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem. 2021 Oct;297(4):101196. doi: 10.1016/j.jbc.2021.101196. Epub 2021 Sep 13. https://pubmed.ncbi.nlm.nih.gov/34529976/
  • Gil S, Goessler K, Dantas WS, Murai IH, Merege-Filho CAA, Pereira RMR, de Cleva R, Santo MA, Kirwan JP, Roschel H, Gualano B. Constraints of Weight Loss as a Marker of Bariatric Surgery Success: An Exploratory Study. Front Physiol. 2021 Jun 11;12:640191. doi: 10.3389/fphys.2021.640191. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34177607/
  • Axelrod CL, Fealy CE, Erickson ML, Davuluri G, Fujioka H, Dantas WS, Huang E, Pergola K, Mey JT, King WT, Mulya A, Hsia D, Burguera B, Tandler B, Hoppel CL, Kirwan JP. Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans. Metabolism. 2021 Aug;121:154803. doi: 10.1016/j.metabol.2021.154803. Epub 2021 Jun 4. https://pubmed.ncbi.nlm.nih.gov/34090870/
  • Kirwan JP, Axelrod CL, Kullman EL, Malin SK, Dantas WS, Pergola K, Del Rincon JP, Brethauer SA, Kashyap SR, Schauer PR. Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults With Type 2 Diabetes. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4192-e4201. doi:10.1210/clinem/dgab255. https://pubmed.ncbi.nlm.nih.gov/33870426/
  • Gil S, Peçanha T, Dantas WS, Murai IH, Merege-Filho CAA, de Sá-Pinto AL, Pereira RMR, de Cleva R, Santo MA, Rezende DAN, Kirwan JP, Gualano B, Roschel H. Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function. Obes Surg. 2021 Mar;31(3):1381-1386. doi: 10.1007/s11695-020-05053-7. Epub 2020 Oct 27. https://pubmed.ncbi.nlm.nih.gov/33111247/

2020

  • Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP. BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med. 2020 Jul 7;12(7):e12088. doi: 10.15252/emmm.202012088. Epub 2020 Jun 10. https://pubmed.ncbi.nlm.nih.gov/32519812/
  • Dantas WS, Roschel H, Murai IH, Gil S, Davuluri G, Axelrod CL, Ghosh S, Newman SS, Zhang H, Shinjo SK, das Neves W, Merege-Filho C, Teodoro WR, Capelozzi VL, Pereira RM, Benatti FB, de Sá-Pinto AL, de Cleva R, Santo MA, Kirwan JP, Gualano B. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes. 2020 Aug;69(8):1675-1691. doi: 10.2337/db19-1180. Epub 2020 May 14. https://pubmed.ncbi.nlm.nih.gov/32409493/
  • Nicoletti CF, Cortes-Oliveira C, Noronha NY, Pinhel MAS, Dantas WS, Jácome A, Marchini JS, Gualano B, Crujeiras AB, Nonino CB. DNA methylation pattern changes following a short-term hypocaloric diet in women with obesity. Eur J Clin Nutr. 2020 Sep;74(9):1345-1353. doi: 10.1038/s41430-020-0660-1. Epub 2020 May 13. https://pubmed.ncbi.nlm.nih.gov/32404903/

2019

  • Murai IH, Roschel H, Dantas WS, Gil S, Merege-Filho C, de Cleva R, de Sá-Pinto AL, Lima F, Santo MA, Benatti FB, Kirwan JP, Pereira RM, Gualano B. Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2019 Oct 1;104(10):4639-4650. doi: 10.1210/jc.2019-00074. https://pubmed.ncbi.nlm.nih.gov/31322672/
  • Dantas WS, Neves WD, Gil S, Barcellos CRG, Rocha MP, de Sá-Pinto AL, Roschel H, Gualano B. Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome. Cytokine. 2019 Aug;120:66-70. doi: 10.1016/j.cyto.2019.04.006. Epub 2019 Apr 18. https://pubmed.ncbi.nlm.nih.gov/31005728/

2018

  • Dantas WS, Gil S, Murai IH, Costa-Hong V, Peçanha T, Merege-Filho CAA, de Sá-Pinto AL, de Cleva R, Santo MA, Pereira RMR, Kirwan JP, Roschel H, Gualano B. Reversal of Improved Endothelial Function After Bariatric Surgery Is Mitigated by Exercise Training. J Am Coll Cardiol. 2018 Oct 30;72(18):2278-2279. doi:10.1016/j.jacc.2018.07.094. https://pubmed.ncbi.nlm.nih.gov/30360835/
  • Dolan E, Saunders B, Dantas WS, Murai IH, Roschel H, Artioli GG, Harris R, Bicudo JEPW, Sale C, Gualano B. A Comparative Study of Hummingbirds and Chickens Provides Mechanistic Insight on the Histidine Containing Dipeptide Role in Skeletal Muscle Metabolism. Sci Rep. 2018 Oct 3;8(1):14788. doi: 10.1038/s41598-018-32636-3. https://pubmed.ncbi.nlm.nih.gov/30283073/
  • Benatti FB, Miyake CNH, Dantas WS, Zambelli VO, Shinjo SK, Pereira RMR, Silva MER, Sá-Pinto AL, Borba E, Bonfá E, Gualano B. Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial. Front Immunol. 2018 Apr 27;9:906. doi: 10.3389/fimmu.2018.00906. eCollection 2018. https://pubmed.ncbi.nlm.nih.gov/29755474/
  • Miyake CNH, Gualano B, Dantas WS, Pereira RT, Neves W, Zambelli VO, Shinjo SK, Pereira RM, Silva ER, Sá-Pinto AL, Borba E, Roschel H, Bonfá E, Benatti FB. Increased Insulin Resistance and Glucagon Levels in Mild/Inactive Systemic Lupus Erythematosus Patients Despite Normal Glucose Tolerance. Arthritis Care Res (Hoboken). 2018 Jan;70(1):114-124. doi: 10.1002/acr.23237. Epub 2017 Dec 6. https://pubmed.ncbi.nlm.nih.gov/28320046/

2017

  • Yance VRV, Marcondes JAM, Rocha MP, Barcellos CRG, Dantas WS, Avila AFA, Baroni RH, Carvalho FM, Hayashida SAY, Mendonca BB, Domenice S. Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies. Eur J Endocrinol. 2017 Jul;177(1):93-102. doi: 10.1530/EJE-17-0111. Epub 2017 Apr 21. https://pubmed.ncbi.nlm.nih.gov/28432270/
  • Dantas WS, Murai IH, Perandini LA, Azevedo H, Moreira-Filho CA, Camara NO, Roschel H, Gualano B. Acute exercise elicits differential expression of insulin resistance genes in the skeletal muscle of patients with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2017 May;86(5):688-697. doi: 10.1111/cen.13307. Epub 2017 Mar 16.  https://pubmed.ncbi.nlm.nih.gov/28177124/

2015

  • Dantas WS, Marcondes JA, Shinjo SK, Perandini LA, Zambelli VO, Neves WD, Barcellos CR, Rocha MP, Yance Vdos R, Pereira RT, Murai IH, Pinto AL, Roschel H, Gualano B. GLUT4 translocation is not impaired after acute exercise in skeletal muscle of women with obesity and polycystic ovary syndrome. Obesity (Silver Spring). 2015 Nov;23(11):2207-15. doi: 10.1002/oby.21217. Epub 2015 Sep 16. https://pubmed.ncbi.nlm.nih.gov/26373822/
  • Barcellos CR, Rocha MP, Hayashida SA, Dantas WS, Dos Reis Vieira Yance V, Marcondes JA. Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors. Hormones (Athens). 2015 Apr-Jun;14(2):251-7. doi:10.14310/horm.2002.1584. https://pubmed.ncbi.nlm.nih.gov/26158655/
  • Pereira RT, Dörr FA, Pinto E, Solis MY, Artioli GG, Fernandes AL, Murai IH, Dantas WS, Seguro AC, Santinho MA, Roschel H, Carpentier A, Poortmans JR, Gualano B. Can creatine supplementation form carcinogenic heterocyclic amines in humans? J Physiol. 2015 Sep 1;593(17):3959-71. doi: 10.1113/JP270861. Epub 2015 Jul 30. https://pubmed.ncbi.nlm.nih.gov/26148133/
  • Murai IH, Roschel H, Pabis LV, Takayama L, de Oliveira RB, Dos Santos Pereira RT, Dantas WS, Pereira RM, Jorgetti V, Ballester RY, Gualano B. Exercise training, creatine supplementation, and bone health in ovariectomized rats. Osteoporos Int. 2015 Apr;26(4):1395-404. doi: 10.1007/s00198-014-3017-6. Epub 2015 Jan 14. https://pubmed.ncbi.nlm.nih.gov/25586761/

2013

  • Dantas WS, Gualano B, Rocha MP, Barcellos CR, dos Reis Vieira Yance V, Marcondes JA. Metabolic disturbance in PCOS: clinical and molecular effects on skeletal muscle tissue. ScientificWorldJournal. 2013 Jun 5;2013:178364. doi: 10.1155/2013/178364. Print 2013. https://pubmed.ncbi.nlm.nih.gov/23844380/