Welcome!

The Integrative Molecular Physiology Lab in the Department of Human Physiology at the University of Oregon provides diverse research and learning experiences that emphasize cellular and molecular processes, underscoring the coordinated integration of organ systems within the body, typically to unravel disease mechanisms.

Our lab takes a systems-level approach to chart the signaling networks that regulate mitochondrial function, which in turn governs metabolism in health, aging, and disease. We are also interested in dissecting how muscle contraction positively changes mitochondrial function and how it affects the heart and brain. We use cutting-edge biological tools to investigate a range of model organisms, from mice to humans. Our research has led to the creation of innovative methodologies, including multi-layered, cross-species genetics/omics gene mapping techniques. This has significantly advanced our understanding of how signaling pathways influence mitochondrial function, quality control, and metabolism. While we explore fundamental biomedical questions, we strongly emphasize innovation. My scientific background supports translating our findings into new preventive and therapeutic strategies for common conditions such as type 2 diabetes, frailty, Alzheimer’s disease, cardiovascular disease, and obesity.

At our lab, we believe science is for everyone, including you! Interested in joining us? Please contact Dr. Wagner S. Dantas (wdantas@uoregon.edu) about graduate student and other research opportunities in the lab. Please e-mail me if you are interested.