The paper this week is the OPRD synthesis of Ubrogepant, the first drub approved by the FDA for migraines as they’re currently happening, rather than as a preventative measure. Main paper: https://pubs.acs.org/doi/10.1021/acs.oprd.7b00293 A couple supporting papers if interested: https://www.nejm.org/doi/full/10.1056/NEJMoa1813049 and… Continue Reading
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This week we will be reading about host-guest-induced electron transfer for catalysis using metal-organic cages (https://doi.org/10.1021/jacs.9b11273). As always we will meet at Roma at 8:30 on Wednesday!
Hello! This week we will be talking about photoredox and cross-coupling dual catalysis out of the Rueping group. Link for paper: https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201911109. See you at Roma’s at 8:30am on Wednesday!
This week we will be talking about photoredox chemistry as a method to access late-state fluorination! The paper comes from Tobias Ritter’s group at the Max Planck Institute in Germany. Link to paper: https://www.nature.com/articles/s41557-019-0353-3. Hope to see you at Roma’s… Continue Reading
This week we will be talking about mechanically triggered small molecule release from the Robb group at Cal Tech. Paper: https://pubs.acs.org/doi/10.1021/jacs.9b08663. See you on Tuesday at 8:30am at Roma’s!
This week we will be talking about remote carboxylation with CO2! There are two papers from the Martin group in Spain that investigate Ni-catalyzed remote carboxylation from either alkyl bromide or alkene starting materials. 1. Site-Selective Catalytic Carboxylation of Unsaturated… Continue Reading
This week we will be talking about the Synthesis of Isomerically Pure (Z)‑Alkenes from Terminal Alkynes and Terminal Alkenes: Silver-Catalyzed Hydroalkylation of Alkynes from Gojko Lalic’s group up in Washington. Main paper: https://pubs.acs.org/doi/10.1021/jacs.9b09336. See you at Roma’s at 8:30am tomorrow!
This week we will be talking about a paper from Christo Sevov’s group at The Ohio State University. The paper uses electricity as a means to enable the use of nickel complexes (as opposed to palladium) as catalysts fro the… Continue Reading
This week we will be talking about palladium catalyzed cycloaddition reactions to access enantioenriched isoquinolines! This is coming from the Gulías and Mascareñas groups from the Universidade de Santiago de Compostela in Spain. Link for paper: https://pubs.acs.org/doi/10.1021/jacs.8b12636. Hope to see… Continue Reading