Typically, architects and designers focus on designing physical space while scientists focus on understanding the unknown and unseen. Often, these lines of vision and discovery do not cross. In contrast, the Institute for Health in the Built Environment work on projects that integrates designers, scientists and industry partners with diverse backgrounds to explore together the unseen elements of our built environment, including the indoor microbiome, air, chemistry, thermal and visual comfort, perception, psychologic and physiologic response, to understand how to better design for health, energy and evolution. We use science to design the unseen.