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Luke is going to present a nice application of the lattice models that Zach presented last week. In this paper, the authors use lattice models to probe the distribution of possible folded protein sequences across sequence space.  They find a strikingly clumpy distribution that has led to the idea of “superfunnels” in sequence space.

Modeling evolutionary landscapes: Mutational stability, topology, and superfunnels in sequence space

Erich Bornberg-Bauer, Hue Sun Chan

PNAS 1999

http://www.pnas.org/content/96/19/10689.short

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